In the past decade, the discovery of active pharmaceutical substances with high therapeutic value\nbut poor aqueous solubility has increased, thus making it challenging to formulate these\ncompounds as oral dosage forms. The bioavailability of these drugs can be increased by\nformulating these drugs as an amorphous drug delivery system. Use of porous media like\nmesoporous silica has been investigated as a potential means to increase the solubility of poorly\nsoluble drugs and to stabilize the amorphous drug delivery system. These materials have\nnanosized capillaries and the large surface area which enable the materials to accommodate high\ndrug loading and promote the controlled and fast release. Therefore, mesoporous silica has been\nused as a carrier in the solid dispersion to form an amorphous solid dispersion (ASD). Mesoporous\nsilica is also being used as an adsorbent in a conventional solid dispersion, which has many useful\naspects. This review focuses on the use of mesoporous silica in ASD as potential means to\nincrease the dissolution rate and to provide or increase the stability of the ASD. First, an overview\nof mesoporous silica and the classification is discussed. Subsequently, methods of drug\nincorporation, the stability of dispersion and, much more are discussed.
Loading....